1x10 15 Search Results


uncoated culture dishes  (Sarstedt)
86
Sarstedt uncoated culture dishes
Uncoated Culture Dishes, supplied by Sarstedt, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/1x10+15/pmc12830989-227-26-29?v=Sarstedt
Average 86 stars, based on 1 article reviews
uncoated culture dishes - by Bioz Stars, 2026-08
86/100 stars
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chi-square p <1x10 -15  (CH Instruments)
90
CH Instruments chi-square p <1x10 -15
Genes intolerant to LoF have longer and more complex 5’UTRs. A 5’UTRs increase in length with decreasing tolerance to LoF (Wilcoxon P <t><1x10</t> -15 ). The average 5’UTR length across all genes (202 bp) is shown by a dotted line. The y-axis was truncated at 1,500 bp (39 genes had 5’UTRs >1,500 bp). B The 5’UTRs of genes most intolerant to LoF have lower minimum free energy (MFE) scores, representing a higher propensity to fold and create structured mRNAs (Wilcoxon P <1x10 -15 ). The average MFE across all 5’UTRs is shown as a dotted line (-78.8). The y-axis was truncated at -1,000 (6 genes had MFE <-1000). C The 5’UTRs of genes most intolerant to LoF are more conserved. Average PhyloP scores are plotted for 5’UTRs, uORF start codons, uORF stop codons and start-stops. The dotted line denotes PhyloP=2. D Genes most intolerant to LoF are more likely to have <t>uORFs</t> (Chi-square P <1x10 -15 ) and start-stops (Chi-square P =8.5x10 -05 ) than genes most tolerant to LoF. The average numbers of each uAUG type across all 5’UTRs are shown by dotted lines. uORF: upstream open reading frame; oORF; overlapping open reading frame. E Genes most intolerant to LoF were significantly more likely to have multiple associated CAGE peaks when compared to genes most tolerant to LoF (CAGE peak >1, 91.9% vs 72.4%, Chi-square P <1x10 -15 ; CAGE peak ≥6, 44.6% vs 16.3%, Chi-square P <1x10 -15 ). F Whilst Ribo-seq uORFs in genes intolerant to LoF appear to more frequently have canonical start-codons, this difference is not statistically significant (Chi-square P =0.18). All statistical tests compare the lowest and highest two LOEUF deciles
Chi Square P <1x10 15, supplied by CH Instruments, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/1x10+15/pmc11057154-76-11-12?v=CH+Instruments
Average 90 stars, based on 1 article reviews
chi-square p <1x10 -15 - by Bioz Stars, 2026-08
90/100 stars
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rpmi 1640 media  (Corning Life Sciences)
90
Corning Life Sciences rpmi 1640 media
Genes intolerant to LoF have longer and more complex 5’UTRs. A 5’UTRs increase in length with decreasing tolerance to LoF (Wilcoxon P <t><1x10</t> -15 ). The average 5’UTR length across all genes (202 bp) is shown by a dotted line. The y-axis was truncated at 1,500 bp (39 genes had 5’UTRs >1,500 bp). B The 5’UTRs of genes most intolerant to LoF have lower minimum free energy (MFE) scores, representing a higher propensity to fold and create structured mRNAs (Wilcoxon P <1x10 -15 ). The average MFE across all 5’UTRs is shown as a dotted line (-78.8). The y-axis was truncated at -1,000 (6 genes had MFE <-1000). C The 5’UTRs of genes most intolerant to LoF are more conserved. Average PhyloP scores are plotted for 5’UTRs, uORF start codons, uORF stop codons and start-stops. The dotted line denotes PhyloP=2. D Genes most intolerant to LoF are more likely to have <t>uORFs</t> (Chi-square P <1x10 -15 ) and start-stops (Chi-square P =8.5x10 -05 ) than genes most tolerant to LoF. The average numbers of each uAUG type across all 5’UTRs are shown by dotted lines. uORF: upstream open reading frame; oORF; overlapping open reading frame. E Genes most intolerant to LoF were significantly more likely to have multiple associated CAGE peaks when compared to genes most tolerant to LoF (CAGE peak >1, 91.9% vs 72.4%, Chi-square P <1x10 -15 ; CAGE peak ≥6, 44.6% vs 16.3%, Chi-square P <1x10 -15 ). F Whilst Ribo-seq uORFs in genes intolerant to LoF appear to more frequently have canonical start-codons, this difference is not statistically significant (Chi-square P =0.18). All statistical tests compare the lowest and highest two LOEUF deciles
Rpmi 1640 Media, supplied by Corning Life Sciences, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/1x10+15/bio_rxiv__632687-137-12-15?v=Corning+Life+Sciences
Average 90 stars, based on 1 article reviews
rpmi 1640 media - by Bioz Stars, 2026-08
90/100 stars
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ionic strength  (Malvern Panalytical)
99
Malvern Panalytical ionic strength
Genes intolerant to LoF have longer and more complex 5’UTRs. A 5’UTRs increase in length with decreasing tolerance to LoF (Wilcoxon P <t><1x10</t> -15 ). The average 5’UTR length across all genes (202 bp) is shown by a dotted line. The y-axis was truncated at 1,500 bp (39 genes had 5’UTRs >1,500 bp). B The 5’UTRs of genes most intolerant to LoF have lower minimum free energy (MFE) scores, representing a higher propensity to fold and create structured mRNAs (Wilcoxon P <1x10 -15 ). The average MFE across all 5’UTRs is shown as a dotted line (-78.8). The y-axis was truncated at -1,000 (6 genes had MFE <-1000). C The 5’UTRs of genes most intolerant to LoF are more conserved. Average PhyloP scores are plotted for 5’UTRs, uORF start codons, uORF stop codons and start-stops. The dotted line denotes PhyloP=2. D Genes most intolerant to LoF are more likely to have <t>uORFs</t> (Chi-square P <1x10 -15 ) and start-stops (Chi-square P =8.5x10 -05 ) than genes most tolerant to LoF. The average numbers of each uAUG type across all 5’UTRs are shown by dotted lines. uORF: upstream open reading frame; oORF; overlapping open reading frame. E Genes most intolerant to LoF were significantly more likely to have multiple associated CAGE peaks when compared to genes most tolerant to LoF (CAGE peak >1, 91.9% vs 72.4%, Chi-square P <1x10 -15 ; CAGE peak ≥6, 44.6% vs 16.3%, Chi-square P <1x10 -15 ). F Whilst Ribo-seq uORFs in genes intolerant to LoF appear to more frequently have canonical start-codons, this difference is not statistically significant (Chi-square P =0.18). All statistical tests compare the lowest and highest two LOEUF deciles
Ionic Strength, supplied by Malvern Panalytical, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/1x10+15/pm28350173-66-30-41?v=Malvern+Panalytical
Average 99 stars, based on 1 article reviews
ionic strength - by Bioz Stars, 2026-08
99/100 stars
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na na na na na na invernici2018  (ATCC)
96
ATCC na na na na na na invernici2018
Genes intolerant to LoF have longer and more complex 5’UTRs. A 5’UTRs increase in length with decreasing tolerance to LoF (Wilcoxon P <t><1x10</t> -15 ). The average 5’UTR length across all genes (202 bp) is shown by a dotted line. The y-axis was truncated at 1,500 bp (39 genes had 5’UTRs >1,500 bp). B The 5’UTRs of genes most intolerant to LoF have lower minimum free energy (MFE) scores, representing a higher propensity to fold and create structured mRNAs (Wilcoxon P <1x10 -15 ). The average MFE across all 5’UTRs is shown as a dotted line (-78.8). The y-axis was truncated at -1,000 (6 genes had MFE <-1000). C The 5’UTRs of genes most intolerant to LoF are more conserved. Average PhyloP scores are plotted for 5’UTRs, uORF start codons, uORF stop codons and start-stops. The dotted line denotes PhyloP=2. D Genes most intolerant to LoF are more likely to have <t>uORFs</t> (Chi-square P <1x10 -15 ) and start-stops (Chi-square P =8.5x10 -05 ) than genes most tolerant to LoF. The average numbers of each uAUG type across all 5’UTRs are shown by dotted lines. uORF: upstream open reading frame; oORF; overlapping open reading frame. E Genes most intolerant to LoF were significantly more likely to have multiple associated CAGE peaks when compared to genes most tolerant to LoF (CAGE peak >1, 91.9% vs 72.4%, Chi-square P <1x10 -15 ; CAGE peak ≥6, 44.6% vs 16.3%, Chi-square P <1x10 -15 ). F Whilst Ribo-seq uORFs in genes intolerant to LoF appear to more frequently have canonical start-codons, this difference is not statistically significant (Chi-square P =0.18). All statistical tests compare the lowest and highest two LOEUF deciles
Na Na Na Na Na Na Invernici2018, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/1x10+15/pmc11481756__12903_2024_5027_MOESM1_ESM-150-23-16?v=ATCC
Average 96 stars, based on 1 article reviews
na na na na na na invernici2018 - by Bioz Stars, 2026-08
96/100 stars
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t cell medium  (Thermo Fisher)
99
Thermo Fisher t cell medium
Genes intolerant to LoF have longer and more complex 5’UTRs. A 5’UTRs increase in length with decreasing tolerance to LoF (Wilcoxon P <t><1x10</t> -15 ). The average 5’UTR length across all genes (202 bp) is shown by a dotted line. The y-axis was truncated at 1,500 bp (39 genes had 5’UTRs >1,500 bp). B The 5’UTRs of genes most intolerant to LoF have lower minimum free energy (MFE) scores, representing a higher propensity to fold and create structured mRNAs (Wilcoxon P <1x10 -15 ). The average MFE across all 5’UTRs is shown as a dotted line (-78.8). The y-axis was truncated at -1,000 (6 genes had MFE <-1000). C The 5’UTRs of genes most intolerant to LoF are more conserved. Average PhyloP scores are plotted for 5’UTRs, uORF start codons, uORF stop codons and start-stops. The dotted line denotes PhyloP=2. D Genes most intolerant to LoF are more likely to have <t>uORFs</t> (Chi-square P <1x10 -15 ) and start-stops (Chi-square P =8.5x10 -05 ) than genes most tolerant to LoF. The average numbers of each uAUG type across all 5’UTRs are shown by dotted lines. uORF: upstream open reading frame; oORF; overlapping open reading frame. E Genes most intolerant to LoF were significantly more likely to have multiple associated CAGE peaks when compared to genes most tolerant to LoF (CAGE peak >1, 91.9% vs 72.4%, Chi-square P <1x10 -15 ; CAGE peak ≥6, 44.6% vs 16.3%, Chi-square P <1x10 -15 ). F Whilst Ribo-seq uORFs in genes intolerant to LoF appear to more frequently have canonical start-codons, this difference is not statistically significant (Chi-square P =0.18). All statistical tests compare the lowest and highest two LOEUF deciles
T Cell Medium, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/1x10+15/pmc09418858-347-20-49?v=Thermo+Fisher
Average 99 stars, based on 1 article reviews
t cell medium - by Bioz Stars, 2026-08
99/100 stars
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chi-square  (CH Instruments)
90
CH Instruments chi-square
Genes intolerant to LoF have longer and more complex 5’UTRs. A 5’UTRs increase in length with decreasing tolerance to LoF (Wilcoxon P <t><1x10</t> -15 ). The average 5’UTR length across all genes (202 bp) is shown by a dotted line. The y-axis was truncated at 1,500 bp (39 genes had 5’UTRs >1,500 bp). B The 5’UTRs of genes most intolerant to LoF have lower minimum free energy (MFE) scores, representing a higher propensity to fold and create structured mRNAs (Wilcoxon P <1x10 -15 ). The average MFE across all 5’UTRs is shown as a dotted line (-78.8). The y-axis was truncated at -1,000 (6 genes had MFE <-1000). C The 5’UTRs of genes most intolerant to LoF are more conserved. Average PhyloP scores are plotted for 5’UTRs, uORF start codons, uORF stop codons and start-stops. The dotted line denotes PhyloP=2. D Genes most intolerant to LoF are more likely to have <t>uORFs</t> (Chi-square P <1x10 -15 ) and start-stops (Chi-square P =8.5x10 -05 ) than genes most tolerant to LoF. The average numbers of each uAUG type across all 5’UTRs are shown by dotted lines. uORF: upstream open reading frame; oORF; overlapping open reading frame. E Genes most intolerant to LoF were significantly more likely to have multiple associated CAGE peaks when compared to genes most tolerant to LoF (CAGE peak >1, 91.9% vs 72.4%, Chi-square P <1x10 -15 ; CAGE peak ≥6, 44.6% vs 16.3%, Chi-square P <1x10 -15 ). F Whilst Ribo-seq uORFs in genes intolerant to LoF appear to more frequently have canonical start-codons, this difference is not statistically significant (Chi-square P =0.18). All statistical tests compare the lowest and highest two LOEUF deciles
Chi Square, supplied by CH Instruments, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/1x10+15/pmc11057154__13059_2024_3248_MOESM2_ESM-16-10-12?v=CH+Instruments
Average 90 stars, based on 1 article reviews
chi-square - by Bioz Stars, 2026-08
90/100 stars
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x-vivotm 15 medium  (Lonza)
90
Lonza x-vivotm 15 medium
Genes intolerant to LoF have longer and more complex 5’UTRs. A 5’UTRs increase in length with decreasing tolerance to LoF (Wilcoxon P <t><1x10</t> -15 ). The average 5’UTR length across all genes (202 bp) is shown by a dotted line. The y-axis was truncated at 1,500 bp (39 genes had 5’UTRs >1,500 bp). B The 5’UTRs of genes most intolerant to LoF have lower minimum free energy (MFE) scores, representing a higher propensity to fold and create structured mRNAs (Wilcoxon P <1x10 -15 ). The average MFE across all 5’UTRs is shown as a dotted line (-78.8). The y-axis was truncated at -1,000 (6 genes had MFE <-1000). C The 5’UTRs of genes most intolerant to LoF are more conserved. Average PhyloP scores are plotted for 5’UTRs, uORF start codons, uORF stop codons and start-stops. The dotted line denotes PhyloP=2. D Genes most intolerant to LoF are more likely to have <t>uORFs</t> (Chi-square P <1x10 -15 ) and start-stops (Chi-square P =8.5x10 -05 ) than genes most tolerant to LoF. The average numbers of each uAUG type across all 5’UTRs are shown by dotted lines. uORF: upstream open reading frame; oORF; overlapping open reading frame. E Genes most intolerant to LoF were significantly more likely to have multiple associated CAGE peaks when compared to genes most tolerant to LoF (CAGE peak >1, 91.9% vs 72.4%, Chi-square P <1x10 -15 ; CAGE peak ≥6, 44.6% vs 16.3%, Chi-square P <1x10 -15 ). F Whilst Ribo-seq uORFs in genes intolerant to LoF appear to more frequently have canonical start-codons, this difference is not statistically significant (Chi-square P =0.18). All statistical tests compare the lowest and highest two LOEUF deciles
X Vivotm 15 Medium, supplied by Lonza, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/1x10+15/pmc05732759-110-7-10?v=Lonza
Average 90 stars, based on 1 article reviews
x-vivotm 15 medium - by Bioz Stars, 2026-08
90/100 stars
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x-vivo 15 serum-free hematopoietic cell medium lonza 04-418q  (Lonza)
90
Lonza x-vivo 15 serum-free hematopoietic cell medium lonza 04-418q
Genes intolerant to LoF have longer and more complex 5’UTRs. A 5’UTRs increase in length with decreasing tolerance to LoF (Wilcoxon P <t><1x10</t> -15 ). The average 5’UTR length across all genes (202 bp) is shown by a dotted line. The y-axis was truncated at 1,500 bp (39 genes had 5’UTRs >1,500 bp). B The 5’UTRs of genes most intolerant to LoF have lower minimum free energy (MFE) scores, representing a higher propensity to fold and create structured mRNAs (Wilcoxon P <1x10 -15 ). The average MFE across all 5’UTRs is shown as a dotted line (-78.8). The y-axis was truncated at -1,000 (6 genes had MFE <-1000). C The 5’UTRs of genes most intolerant to LoF are more conserved. Average PhyloP scores are plotted for 5’UTRs, uORF start codons, uORF stop codons and start-stops. The dotted line denotes PhyloP=2. D Genes most intolerant to LoF are more likely to have <t>uORFs</t> (Chi-square P <1x10 -15 ) and start-stops (Chi-square P =8.5x10 -05 ) than genes most tolerant to LoF. The average numbers of each uAUG type across all 5’UTRs are shown by dotted lines. uORF: upstream open reading frame; oORF; overlapping open reading frame. E Genes most intolerant to LoF were significantly more likely to have multiple associated CAGE peaks when compared to genes most tolerant to LoF (CAGE peak >1, 91.9% vs 72.4%, Chi-square P <1x10 -15 ; CAGE peak ≥6, 44.6% vs 16.3%, Chi-square P <1x10 -15 ). F Whilst Ribo-seq uORFs in genes intolerant to LoF appear to more frequently have canonical start-codons, this difference is not statistically significant (Chi-square P =0.18). All statistical tests compare the lowest and highest two LOEUF deciles
X Vivo 15 Serum Free Hematopoietic Cell Medium Lonza 04 418q, supplied by Lonza, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/1x10+15/pmc10983114-579-22-28?v=Lonza
Average 90 stars, based on 1 article reviews
x-vivo 15 serum-free hematopoietic cell medium lonza 04-418q - by Bioz Stars, 2026-08
90/100 stars
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simian il 15  (Genzyme)
86
Genzyme simian il 15
Genes intolerant to LoF have longer and more complex 5’UTRs. A 5’UTRs increase in length with decreasing tolerance to LoF (Wilcoxon P <t><1x10</t> -15 ). The average 5’UTR length across all genes (202 bp) is shown by a dotted line. The y-axis was truncated at 1,500 bp (39 genes had 5’UTRs >1,500 bp). B The 5’UTRs of genes most intolerant to LoF have lower minimum free energy (MFE) scores, representing a higher propensity to fold and create structured mRNAs (Wilcoxon P <1x10 -15 ). The average MFE across all 5’UTRs is shown as a dotted line (-78.8). The y-axis was truncated at -1,000 (6 genes had MFE <-1000). C The 5’UTRs of genes most intolerant to LoF are more conserved. Average PhyloP scores are plotted for 5’UTRs, uORF start codons, uORF stop codons and start-stops. The dotted line denotes PhyloP=2. D Genes most intolerant to LoF are more likely to have <t>uORFs</t> (Chi-square P <1x10 -15 ) and start-stops (Chi-square P =8.5x10 -05 ) than genes most tolerant to LoF. The average numbers of each uAUG type across all 5’UTRs are shown by dotted lines. uORF: upstream open reading frame; oORF; overlapping open reading frame. E Genes most intolerant to LoF were significantly more likely to have multiple associated CAGE peaks when compared to genes most tolerant to LoF (CAGE peak >1, 91.9% vs 72.4%, Chi-square P <1x10 -15 ; CAGE peak ≥6, 44.6% vs 16.3%, Chi-square P <1x10 -15 ). F Whilst Ribo-seq uORFs in genes intolerant to LoF appear to more frequently have canonical start-codons, this difference is not statistically significant (Chi-square P =0.18). All statistical tests compare the lowest and highest two LOEUF deciles
Simian Il 15, supplied by Genzyme, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/1x10+15/pm08841452-87-10-21?v=Genzyme
Average 86 stars, based on 1 article reviews
simian il 15 - by Bioz Stars, 2026-08
86/100 stars
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nickel, alloy 105, ø40x15mm  (LGC Standards)
N/A
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recombinant human sox10 protein, myc/ddk-tagged  (Creative BioMart)
N/A
Recombinant Human SOX10, fussed with MYC/DDK tag at C-terminal, was expressed in HEK293 cells.This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in
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Image Search Results


Genes intolerant to LoF have longer and more complex 5’UTRs. A 5’UTRs increase in length with decreasing tolerance to LoF (Wilcoxon P <1x10 -15 ). The average 5’UTR length across all genes (202 bp) is shown by a dotted line. The y-axis was truncated at 1,500 bp (39 genes had 5’UTRs >1,500 bp). B The 5’UTRs of genes most intolerant to LoF have lower minimum free energy (MFE) scores, representing a higher propensity to fold and create structured mRNAs (Wilcoxon P <1x10 -15 ). The average MFE across all 5’UTRs is shown as a dotted line (-78.8). The y-axis was truncated at -1,000 (6 genes had MFE <-1000). C The 5’UTRs of genes most intolerant to LoF are more conserved. Average PhyloP scores are plotted for 5’UTRs, uORF start codons, uORF stop codons and start-stops. The dotted line denotes PhyloP=2. D Genes most intolerant to LoF are more likely to have uORFs (Chi-square P <1x10 -15 ) and start-stops (Chi-square P =8.5x10 -05 ) than genes most tolerant to LoF. The average numbers of each uAUG type across all 5’UTRs are shown by dotted lines. uORF: upstream open reading frame; oORF; overlapping open reading frame. E Genes most intolerant to LoF were significantly more likely to have multiple associated CAGE peaks when compared to genes most tolerant to LoF (CAGE peak >1, 91.9% vs 72.4%, Chi-square P <1x10 -15 ; CAGE peak ≥6, 44.6% vs 16.3%, Chi-square P <1x10 -15 ). F Whilst Ribo-seq uORFs in genes intolerant to LoF appear to more frequently have canonical start-codons, this difference is not statistically significant (Chi-square P =0.18). All statistical tests compare the lowest and highest two LOEUF deciles

Journal: Genome Biology

Article Title: Differences in 5'untranslated regions highlight the importance of translational regulation of dosage sensitive genes

doi: 10.1186/s13059-024-03248-0

Figure Lengend Snippet: Genes intolerant to LoF have longer and more complex 5’UTRs. A 5’UTRs increase in length with decreasing tolerance to LoF (Wilcoxon P <1x10 -15 ). The average 5’UTR length across all genes (202 bp) is shown by a dotted line. The y-axis was truncated at 1,500 bp (39 genes had 5’UTRs >1,500 bp). B The 5’UTRs of genes most intolerant to LoF have lower minimum free energy (MFE) scores, representing a higher propensity to fold and create structured mRNAs (Wilcoxon P <1x10 -15 ). The average MFE across all 5’UTRs is shown as a dotted line (-78.8). The y-axis was truncated at -1,000 (6 genes had MFE <-1000). C The 5’UTRs of genes most intolerant to LoF are more conserved. Average PhyloP scores are plotted for 5’UTRs, uORF start codons, uORF stop codons and start-stops. The dotted line denotes PhyloP=2. D Genes most intolerant to LoF are more likely to have uORFs (Chi-square P <1x10 -15 ) and start-stops (Chi-square P =8.5x10 -05 ) than genes most tolerant to LoF. The average numbers of each uAUG type across all 5’UTRs are shown by dotted lines. uORF: upstream open reading frame; oORF; overlapping open reading frame. E Genes most intolerant to LoF were significantly more likely to have multiple associated CAGE peaks when compared to genes most tolerant to LoF (CAGE peak >1, 91.9% vs 72.4%, Chi-square P <1x10 -15 ; CAGE peak ≥6, 44.6% vs 16.3%, Chi-square P <1x10 -15 ). F Whilst Ribo-seq uORFs in genes intolerant to LoF appear to more frequently have canonical start-codons, this difference is not statistically significant (Chi-square P =0.18). All statistical tests compare the lowest and highest two LOEUF deciles

Article Snippet: D Genes most intolerant to LoF are more likely to have uORFs (Chi-square P <1x10 -15 ) and start-stops (Chi-square P =8.5x10 -05 ) than genes most tolerant to LoF.

Techniques:

Comparison of 5’UTRs across disease genes sets. A The 5’UTRs of disease genes are significantly longer (Wilcoxon: DD dominant: P <1x10 -15 ; Onc: P =1.5x10 -05 ; TSG: P =2.9x10 -04 ; HS: P <1x10 -15 ; TS: P <1x10 -15 ) with the exception of DD recessive genes which are significantly shorter (Wilcoxon P =2.7x10 -08 ), when compared to the average across all genes. The median 5’UTR length for all genes (136 bp) is shown by the dotted black line. The x-axis was truncated at 2,000 bp (22 genes had 5’UTRs >2,000 bp). B Disease gene 5’UTRs are significantly more conserved (T-test: DD dominant: P <1x10 -15 ; Onc: P =9x10 -06 ; TSG: P =4.3x10 -08 ; HS: P <1x10 -15 ; TS: P <1x10 -15 ) except DD recessive genes which are significantly less conserved (T-test: P =4.9x10 -08 ), compared to all genes. The dotted black line is the median PhyloP score for all genes (0.28). C Disease genes significantly more often contain uORFs (Chi-square: DD dominant: 57.9%, P <1x10 -15 ; TSG=49.4%, P =6.5x10 -05 ; HS=45.7%, P <1x10 -15 ; TS=40.7%, P =1.4x10 -07 ), when compared to all 5’UTRs. Start-stops are only significantly enriched in HS genes ( P =3.1x10 -08 ). The dotted lines mark the percentage of all genes with each uAUG type

Journal: Genome Biology

Article Title: Differences in 5'untranslated regions highlight the importance of translational regulation of dosage sensitive genes

doi: 10.1186/s13059-024-03248-0

Figure Lengend Snippet: Comparison of 5’UTRs across disease genes sets. A The 5’UTRs of disease genes are significantly longer (Wilcoxon: DD dominant: P <1x10 -15 ; Onc: P =1.5x10 -05 ; TSG: P =2.9x10 -04 ; HS: P <1x10 -15 ; TS: P <1x10 -15 ) with the exception of DD recessive genes which are significantly shorter (Wilcoxon P =2.7x10 -08 ), when compared to the average across all genes. The median 5’UTR length for all genes (136 bp) is shown by the dotted black line. The x-axis was truncated at 2,000 bp (22 genes had 5’UTRs >2,000 bp). B Disease gene 5’UTRs are significantly more conserved (T-test: DD dominant: P <1x10 -15 ; Onc: P =9x10 -06 ; TSG: P =4.3x10 -08 ; HS: P <1x10 -15 ; TS: P <1x10 -15 ) except DD recessive genes which are significantly less conserved (T-test: P =4.9x10 -08 ), compared to all genes. The dotted black line is the median PhyloP score for all genes (0.28). C Disease genes significantly more often contain uORFs (Chi-square: DD dominant: 57.9%, P <1x10 -15 ; TSG=49.4%, P =6.5x10 -05 ; HS=45.7%, P <1x10 -15 ; TS=40.7%, P =1.4x10 -07 ), when compared to all 5’UTRs. Start-stops are only significantly enriched in HS genes ( P =3.1x10 -08 ). The dotted lines mark the percentage of all genes with each uAUG type

Article Snippet: D Genes most intolerant to LoF are more likely to have uORFs (Chi-square P <1x10 -15 ) and start-stops (Chi-square P =8.5x10 -05 ) than genes most tolerant to LoF.

Techniques: Comparison